This is a preview of subscription content, log in to check access. Burton BS On the propyl derivatives and decomposition products of ethylacetoacetate. Am Chem J 3: — Google Scholar. Personalised recommendations. Cite chapter How to cite? However the authors state that subsequent studies will be necessary to investigate this mechanism in other seizure models.
PIP3 contributes to cell signalling and has an important regulatory role in acute cellular physiology such as synaptic transmission and maintaining basal cellular activity. Dr Vicky Robinson, Chief Executive, NC3Rs said: " This breakthrough reflects the necessity to fund original research to develop alternatives to using animals as models of human disease. The work will help to deliver genuine progress in the 3Rs for epilepsy research.
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiology of Disease. Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid.
Br J Ophthalmol ;97 7 The 'omics' of epigenetic modulation by valproic acid treatment in traumatic brain injury-what we know and what the future holds. Proteomics Clin Appl ;13 6 :e Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.
J Neurochem ; 2 Clinical significance of CYP2C9-status guided valproic acid therapy in children. Epilepsia ;56 6 On the propyl derivatives and decomposition products of ethylacetoacetate. Am Chem J ; First clinical trials of the antiepileptic activity of n-dipropylacetic acid. Ann Med Psychol Paris ; Therapeutic potential of valproic acid for retinitis pigmentosa. Br J Ophthalmol ;95 1 Evaluation of muscle strength and motor abilities in children with type II and III spinal muscle atrophy treated with valproic acid.
BMC Neurol ; Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia ;58 4 :e Does valproic acid or levetiracetam improve survival in glioblastoma?
A pooled analysis of prospective clinical trials in newly diagnosed glioblastoma. J Clin Oncol ;34 7 Comedication of valproic acid Is associated with increased metabolism of clozapine. J Clin Psychopharmacol ;38 3 Drug interaction between valproic acid and carbapenems in patients with epileptic seizures. Kaohsiung J Med Sci ;33 3 Valproic acid monotherapy in pregnancy and major congenital malformations.
N Engl J Med ; 23 Thrombocytopenia during intravenous valproic acid therapy in the neurological intensive care unit. J Clin Pharm Ther ;45 5 A meta-analysis of the influence of UGT1A6 genetic polymorphisms on valproic acid pharmacokinetics. Int J Clin Pharmacol Ther ;57 3 Efficacy of oral valproic acid in patients with retinitis pigmentosa.
J Ocul Pharmacol Ther ;30 7 Effect of valproic acid on overall survival in patients with high-grade gliomas undergoing temozolomide: a nationwide population-based cohort study in Taiwan. Medicine Baltimore ;99 28 :e Clinical experience with intravenous valproate as first-line treatment of status epilepticus and seizure clusters in selected populations.
Int J Neurosci ; 1 Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol Phila ;47 2 Sodium valproate may be a treatment for sleep bruxism.
J Child Adolesc Psychopharmacol ;23 9 Therapeutic potential of valproic acid in advanced glaucoma: a pilot study. Indian J Ophthalmol ;66 8 Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med ; 16 Pharmacology of 2-propylvaleric acid. Therapie ; Determination of the optimal concentration of valproic acid in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.
PLoS One ;10 10 :e Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. Ther Drug Monit ;34 5 Prescribing practices of valproic acid for agitation and delirium in the intensive care unit. Ann Pharmacother ;55 3 Reversible encephalopathy caused by valproic acid in an adolescent with idiopathic generalised epilepsy. Rev Neurol ;55 11 Current therapeutic strategy is dominated by thymoregulators. In such long-term therapy where poor compliance constitutes a risk factor for treatment failure, use of valproate valpromide, divalproate has the twin advantage of being easy to manage and well tolerated in the long-term.
During coadministration of thymoregulators, which is often necessary due to their limited individual efficacy, general consensus exists regarding the therapeutic value of combined divalproate and lithium. Abstract The anticonvulsant properties of N-dipropylacetic acid valproic acid were discovered in by Meunier and Carraz.
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