The review cited above found that the most commonly reported side effects were dry mouth and daytime sleepiness. However, the authors also indicated that even low doses of quetiapine can cause significant weight gain. Other undesirable side effects that have been reported in clinical trials of quetiapine for insomnia include:. Side effects associated with higher doses of quetiapine used to treat bipolar disorder and schizophrenia are more well-known. They can include:.
Quetiapine also presents serious risks to people who have dementia, such as increased cognitive decline and death. Prescription sleep aids can make it easier for you to fall asleep or stay asleep.
Prescription options include benzodiazepines and drugs with sedative effects, like antidepressants. In addition, prescription sleeping pills can cause side effects like daytime drowsiness. Some people use nonprescription drugs that cause drowsiness to help them sleep. These include antihistamines and nausea drugs , such as dimenhydrinate. Melatonin is a dietary supplement that is frequently used as a sleep aid.
Other natural sleep aids include:. While supplements may carry a lower risk of serious side effects, they can interfere with other medications you may be taking. Sometimes, making small changes to your daily routine can help improve your sleep. Try the following:. Insomnia apps can help you track your sleep patterns.
Some apps also offer relaxation techniques and hypnosis to help you fall asleep. Similarly, insomnia podcasts can help you wind down before bed. Several case reports on adverse effects with low doses of the drug were also included. Data synthesis: Quetiapine is commonly used off-label for treatment of insomnia.
At recommended doses, atypical antipsychotics such as quetiapine are associated with metabolic adverse events diabetes, obesity, hyperlipidemia. Adverse effects in the prospective trials were patient-reported and were minor, including drowsiness and dry mouth; however, the trials were limited by their small sample size and short duration.
They block dopamine D2 receptors, which alleviates symptoms of psychosis such as hallucinations, delusions and thought disorder. Quetiapine is a second-generation antipsychotic drug that also blocks histamine H1 and serotonin type 2A receptors. Antipsychotic drugs, especially first-generation antipsychotics such as haloperidol, fluphenazine and trifluoperazine, can be associated with some serious side effects, such as the neurological disorder tardive dyskinesia.
This involves involuntary movements of the face, tongue and mouth and, less commonly, the limbs, head, neck and trunk. In some cases, tardive dyskinesia may be irreversible. All antipsychotic drugs can also cause neuroleptic malignant syndrome, a neurological disorder which can progress rapidly over 24 to 72 hours. Neuroleptic malignant syndrome can cause instability, altered consciousness, muscle rigidity and even death.
The incidence is greatest in young men. Both first- and second-generation antipsychotics have been reported to contribute to heart arrhythmia , where the electrical impluses co-ordinating your heartbeats malfunction. In a recent large cohort study , researchers reported that antipsychotic drugs, including quetiapine, almost doubled the risk of sudden death from a heart attack. Quetiapine has fewer side effects than first-generation antipsychotics. But recent research and clinical trials have reported considerable risk of metabolic side effects.
These include weight gain, elevation of cholesterol and triglycerides, and diabetes, even when prescribed at recommended doses.
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